Summary: Klinische Immunologie
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Tumor Immunology
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What is the importance of the immune surveilance regarding tumors?
Without surveillance they would accumulate pretty quickly -
What are the effector cells in tumor immunology?
Cytotoxic T-cell (CD8) -
What is the main action of the 'escape' phase in tumor development?
induction of growth factors to block the immune response to the tumor. -
Which cells of the adaptive immune system are involved in tumor immune surveilance?
- Cytotoxic T cells (CD8)
- B cells (physiologic relevance is yet unclear in mouse)
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What is the role of macrophages in tumor immunity?
- attract other cells by cytokine release
- promotion of tumor cells by m2 cells
- attract other cells by cytokine release
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What is the problem of macrophages diversities in interaction with tumors?
Tumors can use m2 macrophages to induce growth factor production. -
Which cells are generally called lymphotoxic cells?
- NK
- NK-T
- gd T cells
- T CD8
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How do NK cells recognize a tumor?
- if MHC-1 is downregulated, the NK cell is less inhibited by the MHC-1 and therefore promoted to activate the apoptis inducing receptor on the cell.
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When does a T cell initiate apoptosis in cells?
Once they recognize abberant protein expressions on the MHC-1 class. -
What are the steps in immunosurveillance by NK or T cells?
- interaction with cell induced by IL-2
- Interaction with the MHC-1 class
- if MHC-1 is down, activation of CD8
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