Absorptive and barrier function

4 important questions on Absorptive and barrier function

What are contributors of the absorptive & barrier function on the villi?

Goblet cells: mucin production;
Intestinal epithelial cells: microvilli (enlarged surface), tight junctions;
Epithelial renewal: from crypt to villi-tip, 4-6 days.

What are contributors of the absorptive & barrier function of adaptive immunity?

Constant sampling of bacteria and food: M-cells or DCs/APC;
T-helper cells, maturation: Treg, Th1, Th2, Th17;
Homeostasis: balanced T-cell repertoire;
Local and systemic immunity.

What is the pertubance amplitude?

The capacity of a system to absorb disturbance and re-organize while undergoing change so as to still retain essentially the same function.
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What is the recovery rate?

The time required for a system to return to an equilibrium or steady-state following a perturbation.

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