PRRs - AMPs

5 important questions on PRRs - AMPs

PRR signalling regulated AMP expression. What is constitutively expressed?

a-defensins

What is TLR-dependent expressed in enterocytes?

Via TLR - MyD88 - NF-kB: a-microbial proteins, such as Reg3G.

What is another pathway of Reg3G expression?

Via innated lymphoid cells in the lamina propria, which sample the lumen and produce IL-22.

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Mucosal barrier regulation: when are mucin and a-microbial genes upregulated?

PAMP recognition by TLR and NOD;
Th1, Th2, Th17 cytokines, IFN, NO.

Mucosal barrier regulation: when are glycolsyltransferase genes upregulated?

Upon induction by T-cell cytokines.

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