Nod-like receptors
5 important questions on Nod-like receptors
What does NOD do in humans, and what does it lead to?
Intracellular pathogen recognition. NF-kB activation or IL-1B and IL-18 production.
What does NOD recognize of pathogens, bacterial or viral?
Bacterial: components of PGN, both Gram+ and Gram--
Viral: ssRNA, which leads to Type 1 IFN production.
What are CLRs and what do they recognize?
C-type lectin receptors, which recognize sugars (B-glucan) of yeast and fungi. Also MAMPs.
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How is B-glucan bound to CLRs like Dectin1?
Either with two CLRs (homodimer), or with CLR+TLR2+6.
What does activation of two Dectin1 receptors lead to?
In MPHs: respiratory burst.
In DCs: IL-10 and IL-2 production, phagocytosis.
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