Nod-like receptors

5 important questions on Nod-like receptors

What does NOD do in humans, and what does it lead to?

Intracellular pathogen recognition. NF-kB activation or IL-1B and IL-18 production.

What does NOD recognize of pathogens, bacterial or viral?

Bacterial: components of PGN, both Gram+ and Gram--
Viral: ssRNA, which leads to Type 1 IFN production.

What are CLRs and what do they recognize?

C-type lectin receptors, which recognize sugars (B-glucan) of yeast and fungi. Also MAMPs.

  • Higher grades + faster learning
  • Never study anything twice
  • 100% sure, 100% understanding
Discover Study Smart

How is B-glucan bound to CLRs like Dectin1?

 

Either with two CLRs (homodimer), or with CLR+TLR2+6.

What does activation of two Dectin1 receptors lead to?

In MPHs: respiratory burst.
In DCs: IL-10 and IL-2 production, phagocytosis.

The question on the page originate from the summary of the following study material:

  • A unique study and practice tool
  • Never study anything twice again
  • Get the grades you hope for
  • 100% sure, 100% understanding
Remember faster, study better. Scientifically proven.
Trustpilot Logo