Peyer's Patch (3rd layer)
5 important questions on Peyer's Patch (3rd layer)
What is the third layer of defense?
Minimizes exposure of resident bacteria to the systemic immune system.
Through anatomical adaptations which contain invading bacteria within the mucosal immune compartment.
Helps to maintain systemic immune ignorance towards the microbiota.
What are Peyer's Patches/MLNs?
Inductive sites of mucosal responses.
Contains B-cells (germinal center/follicles), T-cells around B-cells, and DCs.
Why are there PP's and MLNs in the SI?
Most immune cells are in the SI: this aids nutrient absorption, because it allows the mucus layer to be thinner.
Immune cells also sample food components and microbes to produce sIgA.
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What regions does a PP have, and what cells are present there?
Germinal center and follicle: B-cells
Interfollicle region (IFR): T-cells
Subepithelial dome (SED): DCs
Follicle associated epithelium: DCs
How can oral vaccination provide systemic immunity?
Lymph nodes connect all mucosal tissues: DCs with the vaccine Ag will travel troughout the body to present it, and acticated T and B-cells will also travel the body to achive systemic immunity.
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