Glycolysis and the pentose phosphate pathway (PPP) - Regulation of Glycose: muscle vs liver - Regulation of glycolysis in liver
4 important questions on Glycolysis and the pentose phosphate pathway (PPP) - Regulation of Glycose: muscle vs liver - Regulation of glycolysis in liver
What is the regulation of glycolysis in liver?
- low affinity for glucose (high Km)
- NO product inhibition
Phosphofructokinase-1 (PFK1)
- ATP regulation as in Muscle
- No effect of lactate/low pH
- Citrate inhibits (enhances the effect of ATP)
What is Fructose 2,6-bisphosphate (F 2,6-BP) and what does it do?
- F-2,6-BP is a metabolite that regulates the glycolysis/gluconeogenesis balance in the liver.
- F-2,6-BP is produced by PFK2 and dephosphorylated by FBPase2.
What induces phosphorylation and inactivation of liver pyruvate kinase?
When there is a high levels of glucose, Fructose 1,6-bisphosphate is produces (glycolysis), which stimulates glucose to pyruvate production.
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Which metabolic pathway is only occurring in the liver? Explain the pathway
- Fructokinase is only expressed in liver
- Fructose to Fructose 1-phosphate
- Fructose 1-phosphate to Glyceraldehyde and Dihydroxyacetone phosphate (DHAP)
- Glyceraldehyde to Glyceraldehyde 3-phosphate (GAP)
- make together pyruvate
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