Role of organs in metabolism
8 important questions on Role of organs in metabolism
Which GLUT receptor are on which organs?
GLUT3: Brain
GLUT4: Adipose tissue, Muscle
GLUT1: Red blood cell
What happens to an excess of calories (glucose)?
What is the primary storage of fat? And which hormone tells the brain you have eaten enough?
Leptin (obesity often associated with leptin resistance)
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What is the role of glucagon-like peptide-1 (GLP-1)?
Proglucagon is cleaved into glucagon or GLP-1
What is special about red blood cells and their glucose uptake?
What is the difference between skeletal muscle and heart muscle?
- mainly glucose as substrate
- producer of lactate
- NOT dependent on oxygen (O2)
- Glycerol-3-P shuttle for transport of redox equivalents
Heart muscle
- mainly fatty acids and ketone bodies as substrates
- consumer of lactate
- Dependent on oxygen (O2)
- Malate/aspartate shuttle for transport of redox equivalents
What couples the integration of muscle and liver metabolism?
What is the role of the Glucose-alanine cycle?
Glutamate > Alanine transported from muscle to liver
Nitrogen can also be transported as Glutamine through blood circulation
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