Glycolysis and the pentose phosphate pathway (PPP) - Pentos phosphate pathway

5 important questions on Glycolysis and the pentose phosphate pathway (PPP) - Pentos phosphate pathway

Where does the pentose phosphate path take place?

Cytosol

What are the 2 phases of pentose phosphate path (PPP)?

  1. Oxidative phase (NADPH)
  2. Non oxidative phase (C5 sugars for RNA/DNA synthesis)

How is the oxidative phase regulated? What is the main

2 NADP+ are reduced to NADPH, utilizing the energy from the conversion of glucose 6-phosphate into ribulose 5-phosphate.
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What is the overal reaction of the oxidation phase?

G-6P + 2 NADP+ + H2OR-5P + 2 NADPH + 2H+ + CO2

NADP+ concentration regulates the oxidation phase

What is the overal reaction of the non oxidative phase?

Net reaction: 3 ribulose-5-phosphate → 1 ribose-5-phosphate + 2 xylulose-5-phosphate → 2 fructose-6-phosphate + GAP (glyceraldehyde-3-phosphate)

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