Biochemistry thrombosis and homeostasis - Primary hemostasis

7 important questions on Biochemistry thrombosis and homeostasis - Primary hemostasis

What is primary hemostasis?

Vasoconstriction followed by the rapid formation of a platelet plug
  • comprises VWF dependent adhesion of blood platelets

What are the crucial role of vascular endothelial cells?

  • Barrier function
  • Storage organelles for platelet-binding von Willebrand factor
    • bio-active components

What are Von Willebrand factor used for?

  • Polymers to caputre as much blood platelets possible
  • Helicostructure (fold in circulation), when needed they unfold and the VWF filament is released to caputre platelets

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How are blood platelets made?

Derive from megakaryocytes in the bone marrow
  • Megakaryocytes within the bone marrow from cytoplasmic protrusion which cross the endothelial cell barrier and are subsequently releases as proplatelets in the circulation.
  • Proplateltes develop into platelets

What are the 2 states of blood platelets?

  • Resting state
  • Activated/aggregated state ("glue")

What are the 3 platelet deficiency?

All defect in VWF, Von Willebrand disease
  • GP1b deficiency
  • GP2b deficiency
  • VWF deficiency
    • Type 1/3: absence or decrease of VWF
    • Type 2A: multimer structure affected
    • Type 2B: binding to platelets affected
    • Type 2N: binding to FVIII affected
    • Type 2M: binding to collagen affected

What is Thrombotic thrombocytopenic purpura (TTP)?

Lack of ADAMTS13
  • normally cleaves VWF multimer into small pieces

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