Skin and biomaterial infection - Antibiotics
6 important questions on Skin and biomaterial infection - Antibiotics
What is the target of Penicillins, ampicillin, cephalosporins, bactracin, vancomycin?
What is the target of streptomycin, cholaroamphenicol, erythromycin, tetracyclins, gentamicin, kanamycin?
What is the target of sulfonamide, trimethoprim?
- enzymes metabolic pathways
- folic acids
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What is the target of Quinolones, Rifampin?
- DNA synthesis (replication)
- RNA synthesis (transcription)
Active vs Passive antibiotic resistance
- Enzymes digesting or modifying antibiotics (ß-lactamase, ESBLs Carbapenemases, aminoglycosidase)
- Active excretion of antibiotic, membrane protein pumps
Passive resistance
- Change in target so antibiotic will not bind
- Alternative PBP’s → MRSA
- Point mutations
Explain Horizontal gene transfer of resistance genes
- Conjugative plasmids: sex pili
- (Conjugative) transposons: transposase, “jumping genes”
- Natural competence: uptake foreign naked DNA
- Bacteriophages
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