Biofilms, antimicrobials and resistance - Proteus mirabilis: virulence factors
3 important questions on Biofilms, antimicrobials and resistance - Proteus mirabilis: virulence factors
What is Proteus mirabilis?
- Gram negative bacilli
- Gastrointesitnal bacteria
- Catheter associated urinary tract infection
- Virulence factors
- flagella - motlie, Schwarm bacteria
- fimbriae
- urease - forms urinary stones using urease
What does P. Mirabilis do to form urinary stasis?
- The bacteria produces a lots of ureas, which hydrolyses urea to ammonia (NH3). This leads to a
ammonium production and the urine becomes basic (--> percipitation of Mg-ammonium phosphate), which forms struvite stones, staghorn renal calculi which leads to urinary stasis
Why can the immune system not reach P. Mirabilis?
Biofilm = Neutrophils kan not kill bacterie
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