Biofilms, antimicrobials and resistance - In general: causative agent, clinic, diagnosis
3 important questions on Biofilms, antimicrobials and resistance - In general: causative agent, clinic, diagnosis
Which are the causative agents of urinary tracht infections?
Outside hospital
- E. Coli
- S. Saprophyticus, Gram neg rods (Klebsiella, Proteus)
- E. Coli
- Gram neg: psuedomonas
- Gram pos: S. Aureus, enterococci
What are the E. Coli virulence factors used, for UTI?
- Entry of bacteria via urethra
- Bind to the uroepithelial cells by type 1 and P fimbriae
- Invasion, intracellular multiplication
- Apoptosis and exfoliation of bladder epithelial cells
- Influx of PMNs
- Bacteria goes to the kidney via ureters and binds via P. fimbriase to renal tubular epithelial cells
- Cytokines induced
- E.coli crosses tubular epithelial cell barrier and bacteria gets into the blood
How can you detect UTI?
Golden standard: culture of urine on a plate
- Identification and antibiotic resistance determination
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