Morbillivirus
3 important questions on Morbillivirus
What is a morbillivirus (genus)?
- Measles virus
- Enveloped (-)ssRNA (antisense)
- 6 structural proteins: nucleocapsid protein (N), phosphoprotein (P), matrix protein (M), fusion protein (F), attachment protein (H), and the large error-prone RNA-dependent RNA polymerase protein (L)
- 2 nonstructural proteins: reading frameshift
- Two additional nonstructural proteins (C and V) are encoded in the P transcription unit: C protein is translated from an overlapping reading frame within the P gene, the V protein is initiated from the same start codon as P, but a frameshift is created by mRNA editing.
What is the life cycle/cellular receptors of measles virus?
- Via recpetor binding: SLAM/CD150, Nectin-4, CD46 (luses different receptor to infect lymphocytes, dendritic cells and epithelial cells)
- replication in the cytosol
What is the vaccine against Measles virus?
Live-attenuated genotype A strain
- vaccination/recovery from measles infection = life-long protection from measles virus reinfection
- therefore a children disease
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