Noravirus and Rotavirus

4 important questions on Noravirus and Rotavirus

What is a norovirus?

  • Non-enveloped (+)ssRNA virus
  • can bind to the membrane or pilli form intestinal bacteria because they express sort like HBGA structures
  • acute gastroenteritis
  • transmission through faecal-oral route

What are the steps of host infection Norovirus? How do the virus particle travel?

  1. Ingestion of Norovirus
  2. Intestins
  3. Excretion feces


Travel by vesicule with multiple virus particles inside

What is the life cycle of Norovirus? Cellular receptor binding?

  • attaches over HBGA receptors → glycans expressed on the surface of specific cells
    • HBGAs in blood or saliva/other bodily secretion
  • replicates in B cells, intestinal epithelial cells, macrophage/dendrite cells
  • cleaves of the proteins
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What is a rotavirus?

  • Non-enveloped segmented dsRNA
  • recombination "viral sex" can easily occur due to that rotavirus is a segmented virus
  • 3 layer of capsid to protect virus since it has no envelope
  • Reproduce in viral vector that thy build themselves: virus factory's for replication  in intestine: Enterocytes
  • cause gastroenteritis


Vaccine available which works (not in NL)

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