Noravirus and Rotavirus
4 important questions on Noravirus and Rotavirus
What is a norovirus?
- Non-enveloped (+)ssRNA virus
- can bind to the membrane or pilli form intestinal bacteria because they express sort like HBGA structures
- acute gastroenteritis
- transmission through faecal-oral route
What are the steps of host infection Norovirus? How do the virus particle travel?
- Ingestion of Norovirus
- Intestins
- Excretion feces
Travel by vesicule with multiple virus particles inside
What is the life cycle of Norovirus? Cellular receptor binding?
attaches over HBGA receptors → glycans expressed on the surface of specific cells
- HBGAs in blood or saliva/other bodily secretion
- replicates in B cells, intestinal epithelial cells, macrophage/dendrite cells
- cleaves of the proteins
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What is a rotavirus?
- Non-enveloped segmented dsRNA
- recombination "viral sex" can easily occur due to that rotavirus is a segmented virus
- 3 layer of capsid to protect virus since it has no envelope
- Reproduce in viral vector that thy build themselves: virus factory's for replication in intestine: Enterocytes
- cause gastroenteritis
Vaccine available which works (not in NL)
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