Rahbovirus
5 important questions on Rahbovirus
What is the source of Rhabdoviruses of human death?
- elimination possible by vaccinating dog
- choking, can not swallow
What are Rabies virus its virus particle?
- Enveloped (-)ssRNA virus
- Encodes 5 structural proteins (nucleoprotein, phosphoprotein, matrix protein, glycoprotein and polymerase)
- Viral mRNa are transcribed by polymerase stuttering (stop- and start-signals are located between ORFs) in cytoplasma
small genome can be used for multiple proteins coding
What is the life cycle of RABV (rabies virus)?
- Rhabdoviruses enter the cell via the endocytic pathway
- Both receptor recognition and membrane fusion are mediated by a single transmembrane viral glycoprotein (G)
- Uncoating occurs in the endosome due to low pH inducing fusion between the G-protein and the endosomal membrane, which releases the NC in the cytoplasm
- The L gene encodes the RNA-dependent RNA polymerase (RdRp); together with phospoprotein P it forms the viral replicase complex
- New virus particles bud from the cell
- Higher grades + faster learning
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How does the RABV evade the immune system?
What are the vaccine agains RABV?
- Live-attenuated vaccine (wild animals)
- Inactivated vaccine (human and pets)
The question on the page originate from the summary of the following study material:
- A unique study and practice tool
- Never study anything twice again
- Get the grades you hope for
- 100% sure, 100% understanding
