Synaptic plasticity in learning and memory - Long-term potentiation
3 important questions on Synaptic plasticity in learning and memory - Long-term potentiation
what is associative LTP?
LTP that only affects the one synaps involved, in conjoint activation
how is LTP implemented in a neuron?
many questinos remain, but there may be 3 seperate components:
1. postsynaptic receptors may change to become more responsive to subsequent inputs
2. changes to presynaptic neuron -> maybe by reterograde messenger that goed to presynaptic neuron and increases amount of neurotransmitt released in future
3. for more long-term changes: structural changes in postysyn neuron, maybe strengthening of existing synapses or building new.
what is the relationship of LTP to leaerning?
no consensus in and not a lot of proof that it relates to better memory. best evidence:
1. genetically modificated rats that have more LTP show better learning than normal rats
2. drugs that block LTP can impair animals ability to learn
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