Subcortical dementia
12 important questions on Subcortical dementia
What are treatment options for Parkinson's?
- Psychological (psychoeducation)
- DBS
How is Corticobasal Degeneration, a parkinsonian disorder, characterized?
- Alien hand syndrome
- Dementia: apraxia
- Degeneration basal ganglia
How is Processive Supranuclear Palsy, a parkinsonian disorder, characterized?
- Dementia: fronto-subcortical pattern
- Eye movement disorders - vertical supranuclear palsy, postural instability
- Basal ganglia, brainstem, cerebellum, frontal cortex
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How is Huntingon's disease characterized?
- Excessive unwanted movements - chorea
- Slowing of wanted movements - bradykinesia
Mood and behavior:
- Apathy, irritability, depression, OCD
Cognitive dysfunction:
- Dementia
How are cognitive aspects affected in Huntington's?
- Psychomotor speed: slowness
- Memory: working, defective retrieval
- Language: only affected in later stages
- Emotion recognition: diminished recognition of negative emotions
- Global: only in later stage
What is vascular dementia?
What characterized vascular dementia?
- Mood: intact disease insight - depression 60%
How is CADASIL, a form of vascular dementia, characterized?
- NOTCH3 mutation chromosome 19
- Dementia
- Progressive damage to the brain
How is HCHWA-D, a form of vascular dementia, characterized?
- Also called Katwijkse ziekte
- BetaPP gene mutation chromosome 21
- Dementia
What are symptoms in Normal Pressure Hydrocephalus?
- Gait disturbance
- Urinary incontinence
What are diagnostic criteria for Creuzfeld Jacob's Disease?
- At least two of: myoclonus, visual or cerebellar disorders, piramidal signs, akinetic mutism
- Specific EEG abnormalities or positive 14-3-3-liquor test and duration <2 years
What are diagnostic criteria for variant CJD?
- Duration >6 months
- Routine care
- At least four of: early psychiatric symptoms, persistent painful sensibility disorders, ataxia, myoclonus, chorea or distonia, or dementia
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