Identifying the disease gene in human monogenic disorders - linkage analysis
6 important questions on Identifying the disease gene in human monogenic disorders - linkage analysis
What are gene mapping strategies?
- Linkage analysis for monogenic
- stronly depends on mode of inheritance
- parametric
- multigenerational
- pedigrees
- linkage analysis for complex
- non-parametric
- association analysis
- parental controls
- case-control
Digenic dominat disease?
Differents between linkage and association?
- links the diseased with the marker
- same mutation in one family
- it suspects that the found genes are associated together and teh disease
- same mutation is seeminly unrelated individuals
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What is a major and minor allel frequency ?
Minor allel frequency: the variation that comes second in the population, alternative allele
The process of gene indentification using linkage analysis in families?
- Positional cloning
- first you make an pedigree and get genetic samples and markers
- linkage analysis
- fine mapping
- transcription map
- mutation analysis
What says the LOD score?
- Gives you the significance that the marker is close or not to a region. It gives the region you need to investigate futher.
- thetra = recombination fraction
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