Pedigree
3 important questions on Pedigree
What are clues for X-linked dominant? (6)
- More females are affected (more chance because 2 X chromosomes)
- Males have server symptoms, because 1 X chromosome
- No male-to-male transmission
- Female with disease, hetrozygote, 50% chance to give it to their children.
- Female with disease, homozygote, 100% chance to give it to their children.
- Male with disease, give it 100% to his daughters.
What are clues for Y-linked inheritance?
- Affect only males
- Affected males always have an effected father (unless new mutation)
- All sons of an affected man are affected
What are the clues for mitochondrial inheritance?
- Affects both sexes
- Usaually inherited from an affected mother of de novo mutations
- Father doesn't transmit to any children.
- Clinical manifestations are often higly cariable
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