Autonomous nervous system - Receptors interacting with the autonomous nervous system - Receptors interacting with the sympathetic NV
7 important questions on Autonomous nervous system - Receptors interacting with the autonomous nervous system - Receptors interacting with the sympathetic NV
What are the 6 types of receptors of the sympathetic nervous system (--> stress of body) that can interact with drugs?
(Sympathetic
Pre→ acetylcholine
→ nicotinic ACh receptor
Post→ norepinephrine
→ excitatory / inhibitory)
The interacting drugs are drugs that work like norepinephrine
- Beta1 receptors
- Beta2 receptors
- Beta3 receptors
- Alfa1 receptors
- Alfa2 receptors
- Indirectly acting sympathomimetics
Sympathetic nervous system:
Sympathetic preganglionic neuron releases acetylcholine into the ganglion which stimulates the sympathetic postganglionic neuron via their nicotinic ACh receptors to release norepinephrine.
Norepinephrine / beta1 receptor agonist (drug) --> via beta1 receptors leads to what (1) effect?
What (4) things does a beta1 receptor antagonist of the sympathetic nervous system inhibit --> decrease?
- Decreased blood pressure
- Decreased cardiac output --> decreased AV-conduction
- Decreased peripheral circulation
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What (1) thing does a beta2 receptor agonist of the sympathetic nervous system stimulate?
What (1) thing does a beta2 receptor antagonist of the sympathetic nervous system stimulate?
What (3) things does a beta3 receptor agonist of the sympathetic nervous system stimulate - in rodents?
Effectiveness in humans not yet found, because of receptor selectivity and species-specific types of fat tissue
- Thermogenic activity (increased heat production)
- Anti-obesity effects
- Insulin-sensitizing effects
What kind of drug that interacts with beta3 receptors of the sympathetic nervous system may activate human brown adipose tissue, which may produce the results in humans that have already been shown possible in rodents?
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