Artikel Change in contractile properties and fatigue

11 important questions on Artikel Change in contractile properties and fatigue

Name a characteristic of a fatigued muscle:

  • Delayed/Slowed Relaxation
  • Decrease in Vmax unloaded
  • Lower Peak Force

What may cause the slower relaxation of a muscle during fatigue?

The decreased rate of cross-bridge detachment.

Name two hypotheses concerning the slow relaxation from isometric contractions of a fatigued muscle.

  • Ca2+ removal rate is decreased
  • cross-bridge detachment rate is decreased
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What hypothesis do Jones et al. (2006) concerning the mechanism behind slow relaxation of a fatigued muscle favor?

They favor the hypothesis about the decreased cross-bridge detachment.

How is a decreased cross-bridge detachment rate reflected in the Force-Velocity relationship?

  • Vmax will be lower and therefore the endpoint will shift to the left

How did the authors (Jones, 2006) define 'relaxation rate'?

highest value of the differentiated force signal during relaxation from an isometric contraction.

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Why did the authors of the Jones article (2006) have to redo their hypothesis?

The changes in Vmax did only weakly correlate with the changes in relaxation rate and loss of power.

How do the authors of the Jones article (2006) explain the changes in a/Fo curvature during muscle fatigue?

Temperature and cross-bridge mechanics.

Explain the cross-bridge mechanics that may underly the changes in a/Fo.

Cross-bridges are made at certain constant rates determined by f(attachment rate) and g1 (detachment rate). These f and g1 are usually in the ratio 4:1. A drop in f could explain the increase in a/Fo as the increase in a/Fo is large.

How can the f be dropped in fatigued muscles?

  1. accumulation of Pi that prevents the powerstroke

What is the take home message of the Jones (2006) article?

Correlation between the changes in relaxation rate and changes in angular velocity / Force in the fatigued state may be due to changes in cross-bridge kinetics

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