DNA methylation - Histone modifications
11 important questions on DNA methylation - Histone modifications
How is DNA organized in the nucleus?
What type of chromatin does muscle-specific gene has in gut and muscle?
What is chromatin remodeling? and name different types of chromatin remodeling proteins
- modifications are primarily located in N-terminal of histone tails
Different type of chromatin remodeling proteins exist:
- histone-modifying complexes
- ATP-dependent chromatin remodeling complexes
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What is the effect and role of histone modifications?
Role: affect gene expresion, hamper amplification transposons, DNA repair, genome stability, prevent cryptic initiation of transcription
What is the main method to detect histone modification?
- Specific antibodies are added to fragmented nucleosome
- then beads are, that will bind to the antibody
- the beads are then isolated and from that DNA is isolated
- securing or qPCR can be done
Give a example of that histone modification do not act alone
- SET1 (H3K4 histone methyl transferase methylates h3k4)
- H3K4me3 facilitates binding NuA3 Histone Acetyl Transferase HAT complex, that acetylates H3K14
How is ChIP-Seq used to annotate genomes?
How does Histone acetylation make chromatin more accessible?
- it facilitates the binding of TF and RNA pol
- Histone deacetylase (HDAC) and Histone acetyltransferase (HAT)
Why is there a bivalent/poised state in embryonic stem cells?
- Presence H3K27me3-Polycomb & H3K4me3-Trx complex
What are the roles of writer, readers and eraser of histone modifications?
How are histone modifying enzymes recruited?
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