Epigenetics, Chromatin & DNA methylation
10 important questions on Epigenetics, Chromatin & DNA methylation
What happens if the epigenetic regulation goed wrong?
- Disturbed development of an organism
- dienares such as cancer
- (trans)gene silencing
- faster aging
Name the chromatin and epigenetic mechanism
- DNA methylation
- histone modification
- acetylation
- methylation
- phosphorylation
- ubiquitylation
- histone variants
- non-coding RNAs
What causes genes to be active in some cells and inactive in others?
- Higher grades + faster learning
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Why are model systems used to study chromatin-based & epigenetic mechanisms?
Why are histone levels low at active TTS?
How does DNA methylation repress transcription activity?
- blocking the binding of transcription factors
- by recruiting DNA methyl-binding proteins
What does a typical DNA methylation landscape look like in mammals?
- Transposable elements and protein-coding regions have DNA methylation
- CpG rich ‘islands’/Promoters/TSSs are unmethylated
What are the methods to detect DNA methylation?
- DNA blot analysis (methylation sensitive restriction enzymes)
- qPCR
- bisulfite sequencing
Genome-wide
- immunolabeling with antibodies against 5mC
- IP using a 5mC antibody with microarray or sequencing
- sequencing DNA methylation-enriched libraries
- genome-wide bisulfite sequencing
What are the targets of 5mC in animal and plant?
plants: CG, CHG (symmetric) and CHH (assymentric)
Why is transposon activity inactive?
The question on the page originate from the summary of the following study material:
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