Translation of mRNA into proteins
11 important questions on Translation of mRNA into proteins
How many reading frames are there?
What does wobble base mean?
What are the difference between prokaryote and eukaryote translation initiation?
Eur: small subunit binds to mRNA and start scanning for kozak consensus (ACCAUGG)
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Explain the reaction that happens in the growing peptide chain
What is the evolution behind virus and ribosomes?
How are incorrect tRNA removed?
How does a polypeptide chain fold into correct conformation?
- Hsp70 protein
- Misfolding can be corrected by hsp60 protein complex
How will incorrecte;y folded proteins or degraded proteins be removed?
What does ubiquitin ligase complex do and what role does F-box play?
- F-box proteins recognize degradation signal in proteins and target this protein to UBI-ligase complex
What are the difference between mono, multi and poly ubiquitylation?
Multi = endocytosis
poly = proteasomal degradation and DNA repair
Which ubiquitin-like protein modifiers that do not target protein for degradation?
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