In dept questions - Extra vragen

6 important questions on In dept questions - Extra vragen

What are the 3 most important characteristics of stem cells?

  • Not terminally differentiated
  • Can divide without a limit
  • Upon division, daughter cells either remain a stem cell, or embarks on a course towards terminal differentiation

What are the differences between embryonic stem cells, induced pluripotent stem cells and somatic stem cells?

Bevruchtte eicel (nog niet gedeeld):
  • Totipotent
  • Can form new organism

Embryonic stem cells:
  • Pluripotent
  • Can form all tissues
  • Cannot form an entire new organism

Gastrula and Adult stem cells:
  • Multipotent
  • Form endo-, meso- and ectoderm

Somatic stem cells:
  • Unipotent
  • Can form one tissue

Induced pluripotent cells:
  • Somatische stamcel gededifferentieerd tot pluripotente stamcel
  • door 4 master regulatoire transcriptie factoren tot expressie te brengen

How are stem cell niches in plants and animals alike?

  • Somatic stem cells are generally located in a stem cell niche: organizer + stem cells
  • Stem cells divide slowly. Differentiating daughter cells divide rapidly before they terminally differentiate: transient amplifying cells
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What is a stem cell niche?

Place where orginizer cells and stem cells are located.

What are transit-amplifying cells?

Stamcellen delen erg langzaam.

Dochtercellen die op weg zijn om gedifferentieerde cellen te worden kunnen, meestal onder invloed van een morphogen, erg snel delen.

Deze snel delende dochtercellen zijn de transit-amplifying cells.

Wat doen Paneth cells (secretory cells) in de stam cell niche?

Ze zorgen ervoor dat de stamcellen stamcellen blijven en niet gaan differentieren.

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