Immune mechanisms
10 important questions on Immune mechanisms
What are the mechanisms behind Kupffer cell-mediated aggravation of liver injury?
- NO production
- releasing of proteases.
- TNF alpha, IL-1beta are generated.
What is the role of dendritic cells in kupffercell activation?
What are gammadelta cells?
- cell-cell contact is required for a proper function.
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What kind of xenobiotics can damage the blood cell develoment?
What are mechanisms of allergic contact dermatitis?
2nd: elicitation phase. 2nd recognition because of memory cells. lympocytes are involved. delayed type.
Via which 3 pathways can the hapten induce an immune response?
2) haptenation can induce a conformational change of the protein.
3) The hapten can modulate the immune system in such a way that the native self peptides will be viewed as though they were nonself peptides and become subject to immune attack (autoimmune reaction).
What are mechanisms of procanoid induced lupus?
1) NAT and then excreted
2) can become bioactivated by myeloperoxidase catalyzed oxidation in white blood cells. this can result in either covalent protein modification or activation of chromatin-reactive T-cells.
What are the mechanisms behind penicilline induced toxicity?
- IgG can be recognized by the Fc receptor of NK killer cells or macrophages.
What are the mechanisms behind halothane induced livertoxicity?
2) cleavage of bromide ion
3) hapten formation
What is oral tolerance?
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