Pentose Phosphate Pathway
7 important questions on Pentose Phosphate Pathway
Where does the pentose phosphate pathway take place?
What is the function of the PPP?
What is the product of phase I (the oxidative phase)?
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How is the oxidative and nonoxidative phase of the PPP controlled?
- Nonoxidative: availability of substrates
Why is a glucose 6-phosphate dehydrogenase deficiency most acute in red blood cells?
Glucose 6-phosphate dehydrogenase is required to maintain reduced glutathione levels to protect against oxidative stress and Heinz bodies (cross-linked hemoglobin molecules).
The PPP is their only source of NADPH.
Cells under oxidative stress need NADPH to reduce oxidized glutathione to monomeric glutathione. NADPH serves as an electron donor to reverse an oxidation reaction (breaking S-S bridges
What does the PPP produce?
By what is PPP activity regulated?
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