Histology liver
14 important questions on Histology liver
The liver receives blood of two systems. Which systems?
- Veins: the hepatic portal vein (nutrient-rich, oxygen-poor blood)
- Hepatic artery (oxygen-rich blood --> for energy)
What is the portal area?
What is the functional unit of the liver?
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Hepatocytes have two nuclei, why?
Why do cell functions in the liver depend on the location in the lobule?
What are the characteristics of the sinusoidal domain?
- Space of Disse
- Many microvilli
- Secretion and uptake of proteins and hormone
What is the pericapillary space (PS)?
What are 5 functions of the liver?
- Bile production
- Lipid metabolism
- Glucose metabolism
- Protein metabolism
- Detoxification
What is the difference between bilirubin and bilirubin glucuronide?
Bilirubin glucuronide is not toxic, it is secreted in the bile to go to the intestines --> feces.
What is lipid metabolism?
What is glucose metabolism?
- Regulation of blood-glucose levels: storage of glucose in glycogen (insulin) or release glucose from glycogen (glucagon).
- Synthesis of glucose: either from other sugars (fructose, galactose) or from non-carbohydrate sources (AA & lipids; gluconeogenesis).
What is protein metabolism? Where does it occur?
- Coagulation factors
- Complement proteins
- Transport-proteins (for metabolites)
What is detoxification? Where does this happen?
Alcohol is cytotoxic for hepatocytes. What are the consequences?
- Inflammation reaction (hepatitis)
- Loss of hepatocytes (peripheral)
- Scarr tissue (cirrhosis)
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