L8 human embryology and developmental biology

14 important questions on L8 human embryology and developmental biology

Was is the first step in gastrularion, so in forming the three germlayers?

The replacement of the hypoblast by defenitive endoderm. (First step gastrulation). Than somewhat later in time still these epiblast cells will dive in and then form the mesoderm between these definitive endoderm and the overlying epiblast.

So of what cells does the embryo actually exists?

Epiblast cells. Everything is replaced by these cells; the hypoderm is replaced bij these cells and the mesoderm is formed by these cells

What will neuralcrest cells become?

Peripheral nerve system, a few become pigment cells etc.. Of the cranial region
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Folic acid is important during pregnancy for?

Closing of the neural tube. (Ofcourse there are many more molecules important then)

At which zone of the neural tube happend most division?

At the ventral site -> to form the huge human brain

From what type of germlayer is the posterior and anterior pituitary formed?

both Ectodermal in nature

In the mesencephalon the motor and sensory tracts are formed. Which one is ventral and which dorsal?

Sensory = dorsal (Alar plate)
Motor = ventral (basal plate)

DA BV

Which structure develops into the three germ layers?

The blastocyst develops into a gastrula with three primary germ layers

Differentiation of the three germ layers

Ectoderm:
epidermis, hair, nails, inner ear, lens, nervous system anterior hypofyse.

Mesoderm:
Epimere (praxial - somites) -> muscles, skeleton, dermis, connective tissue

Mesomere (intermediate) -> urogenital system

Hypomere (later plate) -> muscles, blood/lymphe, spleen, connective tissue, adrenal


Endoderm:
-epithelium of respiratory system
- epithelium of gut, liver, pancreas and urinary tract
- epithelium of pharynx, thyroid, tonsils, inner ear


<- picture: cell and tissue lineages in the mammalian embryo

Development human CNS

Eye development -> develops from diencephalon


Consists of multiple sheets of ectoderm

What are the 5 vesicle of the developing brain?

Telencephalon

Diencephalon
Mesencephalon
Metencephalon
Myecephalon

Out of which structure (brain vesicle) does the pituitary develop?

The Diencephalon

The posterior lobe forms from a diverticulum of the diencephalic floor called the infundibulum, whereas the anterior lobe and pars intermedia form from an evagination of the ectodermal roof of the stomodeum called Rathke's pouch. Rathke's pouch detaches from the stomodeum and becomes associated with the developing posterior pituitary.

Again multiple sheets of ectoderm........

So:
Posterior lobe <- diverticulum diencephalic floor/infudibulum

Anterior lobe/pars intermedia <- evagination of ectodermal roof of stomodeum/Rathke's pouch. 

Medial view of developing brain

Early formation of the cerebral hemispheres in a 10-week embryo. A sagittal section through the brain. B, cross section through the level indicated by the red line in A

Cerebral hemispheres and development


Weetje:Cerebral convolutions

the reason your cerebral cortex has so many folds, like wrinkled-up walnut, is that there is a limited amount of space inside your skull. By wrinkling up, the cortex creates more space to fit in more neurons.

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