Summary: Medical Pharmacology
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Read the summary and the most important questions on Medical Pharmacology
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1. Ιntroduction
This is a preview. There are 3 more flashcards available for chapter 01/12/2019
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What is the pharacological basis of pharmacotherapy?
There is a therapeutic window, the bottom of this window is the minimum effective concentration, the top of this window is the minimum toxic concentration. -
What is the difference between primary and side effect? And how do you determine between these?
Primary effect = effect(s) for which the compound is administered
Side effect = adverse/unwanted effect(s)
The distinction is determined by the aim for which the drug is administered. -
What is a placebo and placebo effect?
A placebo is a preparation without any pharmacologically active substances. When this has a (therapeutic) effect it is called a placebo effect. -
What is a nocebo?
A placebo with unwanted (side) effects. -
2. Receptor theory
This is a preview. There are 10 more flashcards available for chapter 02/12/2019
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What are the four levels of drug action & classification?
- System
- Tissue
- Cellular (transduction)
- Molecular
- System
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How can drugs act on ion channels?
As blocker or modulator -
How can drugs act on enzymes?
As inhibitor, false substrate, and pro-drug -
What are the four receptor families?
- Ligand-gated ion channels (ionotropic receptors)
- G-protein coupled receptors (metabotropic receptors)
- Kinase-linked receptors
- Nuclear receptors
- Ligand-gated ion channels (ionotropic receptors)
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What is the intrinsic activity?
Capacity of a single drug-receptor complex to evoke a response. -
What are the premises of the receptor theory?
- Agonist binds in a reversible manner to its receptor(s)
- Agonist has a very high affinity for its receptor(s)
- Agonist concentration is not altered as a consequence of binding to its receptor(s)
- Agonist efficacy is proportionate to the occupancy grade of its receptor(s) at increasing drug concentrations
- Agonist binds in a reversible manner to its receptor(s)
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