Response variability

8 important questions on Response variability

What is the effect of age on the Vd?

There is a decrease in muscle mass, this leads to decreased distribution and thus Vd is lower.

What is the effect of obesity on the Vd?

There is an increased amount of adipose mass, this leads to increased distribution and thus Vd is higher.

What is the effect on clearance if CYP450 is induced?

There is increased metabolism and thus less clearance.
  • Higher grades + faster learning
  • Never study anything twice
  • 100% sure, 100% understanding
Discover Study Smart

How can a receptor be regulated?

  • Tachyphylaxis
  • Desensitization (homologous or heterologous)
  • Inactivation
  • Down-regulation

What is the effect of long-term treatment of a chronic antagonist?

The receptors are up-regulated.

What is the therapeutic range?

TD50 - ED50

What is the therapeutic index?

TD50/ED50

What is the safety index?

TD1/ED99 (or: TD5/ED95)

The question on the page originate from the summary of the following study material:

  • A unique study and practice tool
  • Never study anything twice again
  • Get the grades you hope for
  • 100% sure, 100% understanding
Remember faster, study better. Scientifically proven.
Trustpilot Logo