Lipid Metabolism - Transport of lipids in the body fluids

8 important questions on Lipid Metabolism - Transport of lipids in the body fluids

What are the two tissue types of the body where large quantities of fat are stored and what is the function of storage? In what form is most of the fat stored?

The adipose tissue and the liver.

Major function of storage in the adipose tissue is storing triglycerides in a liquid form until energy is needed somewhere in the body. Fat storage in the adipose tissue also provides heat insulation and secretion of hormones.

In the liver fatty acids are degraded into small compounds that can be used for energy. Triglycerides are synthesized and other lipids are also synthesized from fatty acids, like cholesterol and phospholipids.

What is the only place where degradation and oxidation of fatty acids can occur? And how much ATP is formed during complete oxidation of 1 molecule of stearic acid (satured molecule)?

The mitochondria and a net gain of 146 molecules of ATP.

What are the two main "rules" for regulation of energy release from triglycerides?

1) Carboydrates are preferred over fats for energy when excess carhobydrates are available .

2) Fat utilization for energy is accelerated in the absence of. Carbohydrates. 
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What are the 3 major types of body phospolipids and what are their functions?

Lecithins, cephalins and sphingomyelin

1) phospholipids are essential for the synthesis of lipoproteins and therefor for the transport of lipids.
2) Thromboplastin, which is essential for initiating the clotting proces is composed mainly of cephalins.
3) Sphinomyelin is used as myelin sheats in the nervous cystem.
4) They donate phosphate radicals
5) Most importantly they participate in the formation of structural elements like cell membranes.

What is the difference between exogenous cholesterol and endogenous cholesterol?

Exogenous: absorbed from food
Endogenous: formed in the cells of the body

What is essential for the liver to be able to remove LDL from the blood?

LDL-receptors determine the amount of circulating LDLs

What is atherosclerosis and what are steps of development of this disease?

Atherosclerosis is when fatty lesions/plaques develop on the inside surface of the arterial wall.

It starts with damage to the vascular endothelium. After which monocytes and lipids (mostly LDLs) begin to accumulate at the site of injury.

What is ketosis? And what are ketonebodies?

Ketosis is a condition which arrises when the levels of ketonebodies rise to a higher level than normal, due to a high fat metabolism.

Examples of ketonebodies are acetoacetic acid, B-hydroxybutyric acid and acetone.

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