MRI : sMRI and DTI - Structural MRI (sMRI)

5 important questions on MRI : sMRI and DTI - Structural MRI (sMRI)

What is he basic idea of sMRI?

Different types of tissue have different physical properties which can be detected with sMRI.

(volume of these tissues differ across pathologies, ages, interventions)

Manual segmentation (way of interpreting MRI results)

  • Labor intensive work
  • requires very good neuroanatomical knowledge
  • done manually by a person, not automatic

Voxel-based morphometry (VBM) (way of interpreting MRI results)

  • A really neat analysis tool
Goals:
  • compare brains on voxel-by-voxel basis
  • identify differences in local composition of brain tissue
  • unbiased/objectif manner
  • more sensitive for localizing small regional differences in gray or white matter
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What is Spatial normalization?

  • Registration of each MRI scan to the same template image by a number of transformations
  • results in Higher-resolution image corrected for global brain shape differences

Example of behavior correlated in sMIR with VBM analysis.

In the patient group high psychopathy scores are associated with lower grey matter volumes in (orbit)frontal and superior temporal region

The question on the page originate from the summary of the following study material:

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