Summary: Microbiology
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Virulence Factors (MIC 9)
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There is a dynamic equilibrium between host and microbes. What is the off-balance called between host and pathogen?
Infectious disease. -
Infection takes place in five steps, give these steps.
- Adherence
- Invasion
- Colonization
- Tissue damage/disease
- Further exposure
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What is the function of a capsule?
A capsule may help with attachment to epithelial cells. -
What are the virulence factors of salmonella that are used for invasion?
- Injectosomes
- Virulence plasmid
- Injectosomes
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Invasion can be performed in several ways. What are two possible ways?
- Zipper mechanism
- Trigger mechanism
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What are the virulence factors of salmonella that are used in step 3, colonization and growth?
- Siderophores
- Anti-phagocytic proteins induced by oxyR
- O antigen
- Vi capsule antigen
- Siderophores
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What is the function of O antigen?
It inhibits phagocyte killing. -
What is the function of Vi capsule antigen?
It inhibits complement binding. -
What is typical for staphylococcus aureus?
It produces fibers that will remain around the infection so it cannot spread. -
What is the advantage of having a capsule?
Having a capsule prevents phagocytosis by bacteria, so they are harder to 'catch'.
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