Nature of cancer
3 important questions on Nature of cancer
What is the dysplastic tissue?
Cells within a dysplasia are usually abnormal cytologically; the appearance of individual cells is no longer normal.
Is seen as the transitional state between completely benign growths and those that are premalignant,
* Polyps, adenomatous polyps, papillomas
* respect the boundary created by the basement membrane
Is seen as the transitional state between completely benign growths and those that are premalignant,
* Polyps, adenomatous polyps, papillomas
* respect the boundary created by the basement membrane
How does tumor progression go?
Normal --> hyperplastic --> dysplastic --> neoplastic --> metastatic
What are some arguments for the monoclonality of tumors?
- Myelomas: derived from B-cell precursor. All the myeloma cells in a patient produce the identical antibody molecule, indicating their descent from a single, common ancestor.
- Have the same peculiar chromosomal abnormality ; the clear result of a rare genetic accident is seen in all the cancer cells within a tumor mass.
- Have the same peculiar chromosomal abnormality ; the clear result of a rare genetic accident is seen in all the cancer cells within a tumor mass.
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