Class 5 FOP and Activin A
11 important questions on Class 5 FOP and Activin A
What is a maior clinical sign in babies for FOP?
What signalling is disturbed in FOP?
Why does bone biopsies induce even more heterotopic bone formation?
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What is the signaling cascade of FOP?
- mutation BMP (ACVR1)
- changes receptor structure
- inhibitor cannot bind anymore
- hypersignaling and autoactivation
Which gene is the crux in bone formation?
Where is the inhibitor site of ALK2 located?
What is the main difference in terms of signaling in the R206H mutation in ACVR1?
- continuous active receptor
- massive signaling
How come Activin A can stimulate the ACVR1R206H receptor?
What is the normal effect of Activin-A signaling on the BMP receptor?
What is the function of Activin - A?
How is Activin-A involved in heterotopic bone formation after trauma?
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