Class 5 FOP and Activin A

11 important questions on Class 5 FOP and Activin A

What is a maior clinical sign in babies for FOP?

A malformed Big toe.

What signalling is disturbed in FOP?

BMP receptor is auto-signalling while it shouldn't

Why does bone biopsies induce even more heterotopic bone formation?

mutation in the BMP receptor is strongly
  • Higher grades + faster learning
  • Never study anything twice
  • 100% sure, 100% understanding
Discover Study Smart

What is the signaling cascade of FOP?

  • mutation BMP (ACVR1)
  • changes receptor structure
  • inhibitor cannot bind anymore
  • hypersignaling and autoactivation

Which gene is the crux in bone formation?

Runx2

Where is the inhibitor site of ALK2 located?

inside the cells.

What is the main difference in terms of signaling in the R206H mutation in ACVR1?

  1. continuous active receptor
  2. massive signaling

How come Activin A can stimulate the ACVR1R206H receptor?

they do not know yet.

What is the normal effect of Activin-A signaling on the BMP receptor?

It normally inhibits BMP signalling.

What is the function of Activin - A?

bone formation inhibition and inflammatory signalling.

How is Activin-A involved in heterotopic bone formation after trauma?

Activin-A expression is enhanced after trauma, as it is also involved in inflammatory signalling.

The question on the page originate from the summary of the following study material:

  • A unique study and practice tool
  • Never study anything twice again
  • Get the grades you hope for
  • 100% sure, 100% understanding
Remember faster, study better. Scientifically proven.
Trustpilot Logo