Class 6 Practical

10 important questions on Class 6 Practical

What determines whether and how much gene is transcribed?

  • Histone-binding
  • transcription factors
  • promotor region
  • DNA-polymerase
  • methylation
  • repressor/enhancer segments

What determines how much a functional protein is produced by the cell?

  • phosphorylation
  • stability
  • miRNA
  • cleavage of signaling peptides
  • ubiquination

What is cell-cell signalling for?

  • survival
  • growt/mitosis
  • apoptosis
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Is BMP signalling fast or slow?

Fast, as it activates and intracellular signalling cascade.

What kind of molecules can directly dignal to the nucleus?

Hydrophobic molecules (steroids)

How is receptor transduction conducted? (fig 16.13)

  • receptor binding
  • structural transformation with scaffold
  • activation of 2nd messenger
  • second messenger cascades to DNA
  • altered metabolism and gene expression

What is the main on-off switch in the cell?

ATP or GTP

What type of receptor is the BMP receptor?

An enzyme-coupled receptor, because type 1 and type 2 receptor components need to be bound for signalling to occur.

What methods can be used to target/prevent BMP signalling in FOP?

  • Smad inhibitors
  • allele specific RNAi

What does: 'induction of dimerization' mean?

for enzyme-coupled receptors, the linkage of te components of that receptor in a chemical way.

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