DNA Polymorphisms and Human Identification - Bone Marrow Engraftment Testing Using DNA Polymorphisms
5 important questions on DNA Polymorphisms and Human Identification - Bone Marrow Engraftment Testing Using DNA Polymorphisms
Wat is engraftment (enting) testing?
To engraft = enten.
- Allogene beenmergtransplantaties worden gevolgd met behulp van STR.
Uit welke twee delen bestaat engraftment (chimerisme) testing?
- Informatieve analyse vóór transplantatie
- Analyse van implantatie na transplantatie
Wat is pre-transplant informatieve analyse in engraftment testing gebruikmakend van STR?
Welke loci zijn informatief? Degene waarbij de ontvanger andere loci heeft dan de donor.
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Hoe kan een STR-analyse worden geïnterpreteerd voor engraftment testing?
- Een volledige match van allelen met de gastheer duidt op onvoldoende engraftment of het ontbreken van donorcellen,
- de aanwezigheid van donorallelen wijst op een succesvolle engraftment van donorcellen in het gastheerorganisme.
Hoe kan engraftment testing worden geanalyseerd gebruikmakend van STR?
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