Molecular Oncology
4 important questions on Molecular Oncology
Wat is microsatellite instability (MSI)?
Normaal hebben deze STRs een stabiele lengte, bij MSI treden mutaties op die leiden tot een onstabiele lengte. Dit kan het gevolg zijn van fouten in het DNA-herstelmechanisme, met name in het mismatch-repair (MMR) systeem. MMR is verantwoordelijk voor het corrigeren van fouten tijdens DNA-replicatie.
MSI is de productie van nieuwe allelen van ongerepareerde replicatie-fouten.
Wat is loss of heterozygosity (LOH)?
Loss of heterozygosity (LOH) is een fenomeen dat wordt waargenomen in moleculaire oncologie, met name bij kankeronderzoek. Het verwijst naar het verlies van het normale heterozygote genotype op specifieke loci in het genoom van een tumorcel.
Wat zijn genherschikkingen in immunoglobuline zware keten (IgH)?
Immunoglobuline-lichte-ketengenen en T-celreceptorgenen herschikken op een vergelijkbare manier.
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Hoe wordt clonality gedetecteerd gebruikmakend van TCR genherschikkingen?
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