Epithelial-Mesenchymal transition (EMT) - Cell biology and behavior in EMT

3 important questions on Epithelial-Mesenchymal transition (EMT) - Cell biology and behavior in EMT

What are the characteristics and cellular changes associated with EMT?

  • embrynonic cell migration
  • wound healing
  • cancer cel verspreiding
  • activatie of EMT-TFs
  • E-cadherin respression
  • loss-apico-basal polarity
  • invasion and migration
  • low proliferation
  • intravasation en extravasation
  • chemotherapie resistant
  • inflammation

What are the core transcription factor (TF) that induces EMT? What is E- to N-cadherin switch?

Twist TF
  • loss of epithelial markers
  • gain of mesenchymal markers


E- to N-cadherin switch allows interaction with various mesenchmal cell types

  • E-cadherin: Epithelial state
  • N-cadherin: Mesenchymal state

What are the characteristics and cellular changes associated with MET?

  • Organ differentiation
  • epithelial homeostasis
  • metastatic colonization
  • repression of EMT-TFs
  • E-cadherin transcription
  • apico-basal polarity
  • cell-cell adhesion
  • increased proliferation

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