Two tumor cells types in neuroblastoma
4 important questions on Two tumor cells types in neuroblastoma
Tumors are composed of malignant and non-malignant cells
What are the 2 types of cells in neuroblastoma?
- MES cells, originate from neural crest (mesenchymal type cells, migrate)
- ADRN cells, originate from symaptho-adrenal precursor (epithelial type cells, no migrate)
MES, mesenchymal cells
- undifferentiated
- Migration high
- neural-crest like
ADRN, adrenergic cells
- lineage committed
What does PRRX1 induce?
- is a core TF in MES cells
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What SE is associated with the mesenchymal reprogramming?
- MES SEs increased H2K27ac
- ADRN SEs decreased H3K27ac
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