Two tumor cells types in neuroblastoma

4 important questions on Two tumor cells types in neuroblastoma

Tumors are composed of malignant and non-malignant cells

Distinct epigenetic and transcriptional states shape the heterogeneity of cancer cells which reflects developmental differentiation states

What are the 2 types of cells in neuroblastoma?

Genetically identical, but can transdifferentiate spontaneously

  1. MES cells, originate from neural crest (mesenchymal type cells, migrate)
  2. ADRN cells, originate from symaptho-adrenal precursor (epithelial type cells, no migrate)


MES, mesenchymal cells
  • undifferentiated
  • Migration high
  • neural-crest like


ADRN, adrenergic cells
  • lineage committed

What does PRRX1 induce?

PRRX1 induces a mesenchymal transformation and dedifferentiation (ADRN to MES), also known as mesenchymal reprogramming
  • is a core TF in MES cells
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What SE is associated with the mesenchymal reprogramming?

Mesenchymal reprogramming is associate with SE remodeling
  • MES SEs increased H2K27ac
  • ADRN SEs decreased H3K27ac

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