Genes & Intelligence

8 important questions on Genes & Intelligence

What can you say if a trait is heritable?

Genetic relatedness should predict phenotypic relatedness, so individuals that share more genes should also be more alike on the trait

So what do you need to research heritability? Where can find this?

We need variation, thus there must be genetic variants that explain heritability. We can find this in the SNP's

On average how much DNA is shared between people?

99.7%
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What kinds of genetic variation is there?

Single nucleotide variation
-Polymorphism(SNP)
- Single point insertion/deletion
Structural variant
-Copy number variant(duplication or deletion of a row of nucleotides) variant is the amount of copies
-inversion

What is the problem with GWAS?

Many complex traits highly heritable, GWAS detected some genetic variants. But only explain a  fraction of the variation in intelligence
Effects are small, so large samples needed
No functional information, findings in gene deserts

What is the advantage of gene set analysis in comparison to GWAS?

Reduces multiple testing by focusing on SNP in genes and creating functional groups of related genes
Incrases effects sized by looking at joint effects

What are gene deserts and what might there function be?

Genes not coding for proteins, might have regulatory functions.

What is the twin based heritability of IQ?

>60% in adults

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