Neurodegenerative Diseases - Alzheimer
13 important questions on Neurodegenerative Diseases - Alzheimer
What are main symptoms in Alzheimer’s disease?
o Difficulty completing familiar task.
o Memory loss
o Poor judgement
o Difficulty with words
Which brain regions are involved in Alzheimer’s disease?
- Entorhinal Cortex: confusion and memory loss
- Cerebral cortex: Language, reasoning & social behavior
- Amygdala: emotions
What is the function of the tau protein?
- Higher grades + faster learning
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What is wrong with tau protein in Alzheimer’s and what is the consequence?
How do the tangles develop?
What is the consequence of the forming of amyloid plaques?
Which mouse model is used to study Alzheimer?
How does plaques form in Alzheimer disease?
The Abeta 40/42 peptide interacts with APOE with aggregation of A beta oligomers and that’s results in amyloid plaque.
What is the consequence of the Abeta 40/42 interaction with the mGluR5, NMDAR, Alpha-7-nAChR and Ros generation oxidative damage?
o Disrupted Ca2+ ion homeostasis.
o Dysregulated energy and glucose metabolism
o Mitochondria oxidative stress
o Neuronal apoptosis dementia or memory loss.
What is a amyloid-beta precursor protein?
What is the function of AICD that is generated after the formation of secretase complex?
How do the tangles develop?
Which mouse model is used to study Alzheimer’s?
The question on the page originate from the summary of the following study material:
- A unique study and practice tool
- Never study anything twice again
- Get the grades you hope for
- 100% sure, 100% understanding
