Neurodegenerative Diseases - miRNA
6 important questions on Neurodegenerative Diseases - miRNA
What is the function of microRNA?
- RNA splicing
- Post-transcriptional regulation of gene-expression
What is gene silencing?
How does a miRNA switch off genes?
- Cutting the mRNA that it is bound to so it can't be translated
- Inhibit ribosome binding to the other subunit so it can be translated.
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In which way can a miRNA regulate the gene expression?
MicroRNA forms a complex with the AGO2 protein in the cytoplasm which then interacts to form a RISC molecule. This RISC molecule can then be used to regulate the gene expression, because the microRNA is complementary to the mRNA that is going to be targeted.
In which way can a miRNA regulate the gene expression?
MicroRNA forms a complex with the AGO2 protein in the cytoplasm which then interacts to form a RISC molecule. This RISC molecule can then be used to regulate the gene expression, because the microRNA is complementary to the mRNA that is going to be targeted.
What does the RNA inducing silencing (RISC) complex do?
- Degrading messenger RNA molecules
- Translational repression: inhibit ribosome recruitment/function
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