Hippocampus - Gene regulation in the brain
10 important questions on Hippocampus - Gene regulation in the brain
Which are the proteins that are mostly produced by neurons that are not matured yet?
Which are the proteins that are mostly produced by differentiated (matured) neurons?
What is the process of protein expression?
- First there is a signal that will unfold the chromatin into euchromatin
- The DNA is transcribed into RNA.
- RNA processing takes place and mRNA is transported out of the nucleus to the cytoplasm.
- In the cytoplasm mRNA is translated into polypeptide chain.
- The protein is then processed into an active protein and transported to the cellular destination where it can fulfill the cellular functions.
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In which three processes can DNA be made available for transcriptions?
- Acetylation
- Methylations
- Phosphorylation.
How is gene expression regulated on DNA level?
The way how chromatin is folded determines whether it can be translated or not. When it needs to be translated the histone tails will protrude outward an acetylation takes place which promotes the loose the chromatin structures which makes it available for DNA transcription
What can happen when the epigenetic regulations are not in balance?
What are some examples of proteins that are always needed in the cell?
- Transport proteins.
- Postsynaptic density proteins
- AMPAR subunits
What is important in neuronal and synaptic plasticity?
How is the number of proteins in a cell regulated?
The number or proteins in a cell is regulated by the protein degradation with use of proteases.
How is the formation of active proteins regulated?
By post- translation protein modification, where proteins are being tagged with a chemical group which can affect their behavior or degraded are being degraded.
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