Neurodegenerative Diseases - Schizophrenia

6 important questions on Neurodegenerative Diseases - Schizophrenia

Which neurotransmitter are dysregulated in schizophrenia?

o Increased dopamine
o Increased Serotonin
o Decreased Glutamate
o Reduced GABA

Which brain abnormalities does a person with schizophrenia may have?

Decreased grey matter in temporal and parietal lobes.

What is the difference between the mesolimbic pathway and the mesocortical pathway and his role in schizophrenia?

The mesolimbic pathway is the dopaminergic pathway that projects from the ventral tegmental area to limbic regions of the brain and is thought to contribute to the positive symptoms while the mesocortical pathway originate in the VTS and projects to prefrontal cortex and is thought to function in the negative symptoms.
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What does the serotonin hypothesis of schizophrenia?

A chronic widespread stress induced serotonergic overdrive in the cerebral cortex, serotine signaling dysfunction could lead to imbalances in these neurotransmitter systems, contributing to the pathophysiology of schizophrenia.

What does the glutamate hypothesis say?

This hypothesis says that dysfunction in the glutamatergic system plays a significant role in the development of schizophrenia. Abnormalities may lead to altered neural connectivity and synaptic plasticity.

What could be a cause of cognitive dysfunction in schizophrenia (NMDA receptor)?

When there is a decreased expression of certain NMDA receptor subunits there will be an altered composition of the NMDA receptor which leads to the hypo functioning of the NMDA receptor and that will lead to cognitive dysfunction.

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