The CX3CL1-CX3CR1 Axis Promotes Microglia Quiescence and the Neuroprotective Phenotype

5 important questions on The CX3CL1-CX3CR1 Axis Promotes Microglia Quiescence and the Neuroprotective Phenotype

Where is the chemokine CX3CL1 formed and secreted?

formed and secreted by neurons.

What is the role of CX3CL1?

CX3CL1 is thought to gradually inhibit microglia activation status by binding the CX3CR1 expressed solely by microglia (Mizuno, 2003; Cardona, 2006; Jung et al., 2010).

What happens to the microglia activation status of mice that are homozygotous CX3CR1-GFP?

They exhibit increased activation status and have dysregulated responses.
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What is the main function of the CX3CL1-CX3CR1 axis?

regulating the modulation of hippocampal neurogenesis.

What happens to the microglia activation status when the CX3CL1-CX3CR1 axis is down (Bachstetter, 2011)?

The microglia are less inhibited and show prolonged activation and increased cytokine production.

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