Mechanisms for Stress-Evoked Inflammatory/Destructive Microglia activation and hippocampal BDNF Downregulation: serotonin and noradrenalin
7 important questions on Mechanisms for Stress-Evoked Inflammatory/Destructive Microglia activation and hippocampal BDNF Downregulation: serotonin and noradrenalin
What is the functional role of microglia in the healthy CNS?
- facilitate growth and repair
- orchestrate inflammation
- synaptic pruning
How may physical activity promote microglial growth and repair function?
Ziv 2006
How may physical activity prevent unfavorable microglia activation and promote stress robustness?
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- Never study anything twice
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What was the effect of 5-HT injection into the dentate gyrus on BDNF mRNA levels?
How does stimulation of the 5-HT receptor modulate microglia activity?
- It promotes motility (Krabbe et al., 2012)
- It decreased hippocampal BDNF (Duman, 1998; Vayda et al., 1997, 1999)
How does stimulation of the bAR receptor modulate microglia activity?
- it mediates pro-inflammatory cytokine release following stress exposure (Johnson et al., 2005)
How do serotonin and NE interact with glia cells?
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