Mechanisms for Stress Robustness Produced by Physical Activity: CX3CL1-CX3CR1 Axis Modulation

5 important questions on Mechanisms for Stress Robustness Produced by Physical Activity: CX3CL1-CX3CR1 Axis Modulation

What could be the molecular signature of stress robustness produced by physical activity in modulating the CX3CL1-CX3CR1 Axis?

The improved rate of CX3CR1 mRNA levels following stress exposure.

What is the found effect of uncontrollable stress on the CX3CL1-CX3CR1 axis?

The US paradigm produces a persistent Down-regulation of CX3CR1 mRNA expression.

What do they conclude about US exposure to sedentary rats?

  • Decreased BDNF production mediated by 5-HT stimulation
  • Increased motility by 5-HT stimulation
  • Increased production of cytokines by NE activity
  • Persistent CX3CR1 mRNA downregulation
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What do they conclude about US exposure to physical active rats?

  • no excessive 5-HT and NE responses
  • less to no BDNF reductions
  • less motility increases
  • controlled production of inflammatory cytokines
  • rapid recovery of CX3CR1 mRNA expression in microglia

Are their results regarding CX3CR1 recovery strong?

No, not even highly significant

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