Ion Homeostasis

8 important questions on Ion Homeostasis

What might be the fucntion of the astrocyte in the tripartite?

Sensing transmission and actively modulating transmission effects

How do glia communicate with eachother?

Ca2+ waves, K+ waves (spatiall buffering)

How are Calcium waves produced?

  1. ATP/Glu binds P2YR
  2. P2YR --> IP3
  3. IP3 opens intracellular stores of Calcium in ER
  4. Calcium flows via gap-junctions AND induces ATP release
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What do astrocytes respond back to neural messaging in synapses?

with gliotransmitters (glu)

Which receptors are involved in LTP and LTD?

NMDA receptors

What does the NMDA receptor binds?

  • Ca2+
  • Glycine
  • D-serine
  • Glu

Which Ion is really important in LTP generation?

Ca signaling in astrocytes.

Take home message of Calcium signaling in astrocytes?

Calcium signaling is complex, there are many routes possible.

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